The term “pemphigus” comes from the Greek (“pemphix”) and means something like “bubble”. The disease is an autoimmune blistering disease of the skin or mucous membrane.
The cause of the outbreak of such a disease is still unclear. Medication and psychological stress are up for discussion. The body begins to form antibodies against the body’s own structures and molecules. This leads to a disruption of protein synthesis in the cells. An enzyme is formed that breaks down the cell structure of keratinocytes (skin cells that make up around 90% of the epidermis). This creates cavities into which interstitial fluid can flow, which in turn can lead to purulent blisters.
Four types of pemphigus can be distinguished. Of these, however, pemphigus foliaceus occurs most frequently in dogs. At the beginning, skin redness, scales, crusts and weeping eczema can be observed. The location of the pemphigus is characteristic: around the eyes, on the bridge of the nose, around the nostrils and the cracks of the mouth, the ears and the toes. In addition to the initial symptoms of a skin disease, fever and a disturbed general condition may occur. It is also possible that the surface of the skin layer may tear. This makes secondary bacterial infection likely.
If your dog is treated by a veterinarian, the prognosis is quite favorable. After discontinuing therapy, however, it is not uncommon for the disease to relapse.
Allergic or atopic eczema Allergic contact eczemaCheyletiellosisDemodicosisFeed allergyAutumn grass mitesPemphigusSkabies